Clinical Applications

• Post-Anesthesia Care Unit (PACU)

• Intensive Care

• Procedural Sedation

• Pain Management Therapy

• General Care Floor

• And across the Continuum of Care

1. Continuous non-invasive respiratory volume monitoring for the identification of patients at risk for opioid induced respiratory depression and obstructive breathing patterns. Voscopoulos C, MacNabb CM, Freeman J, Galvagno SM, Ladd D, George E. J Trauma Acute Surg. 2014; 77: S208-S215. doi: 10.1097/TA.0000000000000400.

2. Evaluation of a Novel Non-Invasive Respiration Monitor Providing Continuous Measurement of Minute Ventilation in Ambulatory Subjects in a Variety of Clinical Scenarios. Voscopoulos C, Brayanov J. Ladd D, Lalli M, Panasyuk A, Freeman J. Anesth Analg 2013; 117: 91-100

3. Operational Realities in the PACU: Staffing and Monitoring for Safe Post-Operative Care. Weissman C, Freeman J. Anesth Analg. 2014; 119: 1249-1250

1. The application of a novel non-invasive respiratory monitor (ExSpironTM) in the extubation of a patient with persistent upper airway swelling. Williams GW, Sharma A, Chen PR. J Med Cases. 2014; 7:388-391.

3. Non-invasive respiratory volume monitoring in patients with traumatic thoracic injuries. Galvagno S, Brayanov B, Corneille M, Voscopoulos C, Sordo S, Ladd D, Freeman J. Trauma [ePub ahead of Print] October 29, 2014. doi: 10.1177/1460408614551977

1. Monitoring Minute Ventilation versus Respiratory Rate to Measure the Adequacy of Ventilation in Patients Undergoing Upper Endoscopic Procedures. Holley K, MacNabb CM, Georgiadis P, Minaysan H, Shukla A, Mathews D. J Clin Monit Comput. [ePub ahead of Print], doi: 10.1007/s10877-015-9674-y

2. The Use of a Non-Invasive Respiratory Volume Monitor to Assess the Effect of Airway Maneuvers and Propofol on Ventilation during Upper Endoscopy. Holley K, Mathews D, Ladd D, Campana L, Schapiro H. Open J Anesth. 2014; 4: 281-290, doi: 10.4236/ojanes.2014.411041

1. Evaluation of a Novel Non-Invasive Respiration Monitor Providing Continuous Measurement of Minute Ventilation in Ambulatory Subjects in a Variety of Clinical Scenarios. Voscopoulos C, Brayanov J. Ladd D, Lalli M, Panasyuk A, Freeman J. Anesth Analg 2013; 117: 91-100

2. Monitoring Minute Ventilation versus Respiratory Rate to Measure the Adequacy of Ventilation in Patients Undergoing Upper Endoscopic Procedures. Holley K, MacNabb CM, Georgiadis P, Minaysan H, Shukla A, Mathews D. J Clin Monit Comput. (ePub ahead of print), doi: 10.1007/s10877-015-9674-y.

2. Preventing Respiratory Depression. Daniel I. Sessler, M.D. Anesthesiology 2015; 122:484-5

1. Respiratory volume variability prior to opioid administration as an indicator for opioid-induced respiratory depression. Cattano D, Brayanov J, George E. American Thoracic Society, May 2015, Denver, CO. (5/15-5/20)

2. Is Maternal Temperature Rise During Labor Analgesia a Physiological Process Due to Decreased Pulmonary Ventilation? Choi LO, Brayanov J, Palanisamy A, Tsen LC, Kodali BS. Society of Obstetric Anesthesia and Perinatology (5/13-5/17)

3. The use of a non-invasive respiratory volume monitor to identify patients at high-risk for opioid-induced respiratory depression for a low-dose opioid regimen in the PACU. 
Voscopoulos CJ, Ladd D, George E. American Pain Society; May 2015, Palm Springs, CA. (5/12-5/16)

4. Evaluation of a Low-Dose Opioid Regimen Using Respiratory Volume Monitoring. 
Voscopoulos C, Freeman J, George E. Deutscher Anästhesiecongress, May 2015, Dusseldorf, Germany. (5/7-5/9)

5. Non-Invasive Minute Ventilation and End Tidal CO2: Intubated versus Non-Intubated. Brayanov J, Voscopoulos C, George E, Freeman J. Deutscher Anästhesiecongress, May 2015, Dusseldorf, Germany. (5/7-5/9)

6. Early Warning of Respiratory Depression can be used to Reduce False Alarms. Voscopoulos C, Freeman J, George E. Deutscher Anästhesiecongress, May 2015, Dusseldorf, Germany. (5/7-5/9)

7. Quantitative Risk Assessment Algorithm for the Safe Use of Opioids Postoperatively. Hein T, Voscopoulos C, George E, Freeman J. Deutscher Anästhesiecongress , May 2015, Dusseldorf, Germany. (5/7-5/9)

8. Assessment of Respiratory Sufficiency using a Non-Invasive Respiratory Volume Monitor during Upper Endoscopy. Creed WG, Holley K, Eversole D, Mathews D. Society for Ambulatory Anesthesia, April 2015, Scottsdale, AZ. (4/23-4/25)

9. Non-Invasive Respiratory Volume Monitoring in the Post Anesthesia Care Unit and During the First Postoperative Night in Obese Patients. Schumann R, Gupta A, Ladd D, Bonney I. International Anesthesia Research Society, March 2015, Honolulu, HI. (3/21-3/24)

10.Non-invasive respiratory volume monitoring provides advanced warning of respiratory depression and can be used to reduce false alarms. Voscopoulos CJ, Freeman J, George E. International Anesthesia Research Society, March 2015, Honolulu, HI. (3/21-3/24)

11.Evaluation of the relationship between non- invasive minute ventilation and end-tidal co2 in intubated and non-intubated patients. Voscopoulos C, MacNabb CM, George E. International Anesthesia Research Society, March 2015, Honolulu, HI. (3/21-3/24)

12.Respiratory rate is a poor assessment of respiratory status during and after upper endoscopy procedures. Holley K, Brayanov J, Mathews D. International Anesthesia Research Society, March 2015, Honolulu, HI. (3/21-3/24)

13.Non-Invasive respiratory volume monitoring for the identification of patients at risk for opioid-induced respiratory depression and post-operative apnea versus a diagnosis of obstructive sleep apnea. Voscopoulos C, Fleming E, Ladd D, George E. American Academy of Pain Medicine; March 2015, National Harbor, MD. (3/19-3/23)

14.Non-Invasive Respiratory Volume Monitoring to Quantify Respiratory Depression Following Benzodiazepine Administration. Mullen G, MacNabb CM, Ladd D. International Symposium on Intensive Care and Emergency Medicine, March 2015, Brussels, Belgium (3/15-3/20)

15.Cost saving impact of non-invasive respiratory volume monitoring in the detection of opioid-induced respiratory depression. Bliznashki K, Ladd D, Voscopoulos C. American Society of Anesthesiologists: Practice Management Symposium, January 2015, Phoenix, AZ. (1/23-1/25)

16.Respiratory Volume Monitoring: Early Warning of Respiratory Depression & Identifying Oximetry False Alarms. George E, Voscopoulos C, MacNabb CM, Freeman J. Society of Critical Care Medicine: 44th Critical Care Congress; January 2015, Phoenix, AZ. (1/17-1/22)

17.Non-invasive Ventilation Monitoring During Remifentanil Challenge in CyP450-Deficient Patient. 
Philip J, Brayanov J. Society for Technology in Anesthesia, January 2015; Phoenix, AZ.

18.Non-Invasive Respiratory Volume Monitoring Provides Quantitative Measurements that Provide a Better Assessment of Ventilatory Status than Capnography-Generated Respiratory Rates. Voscopoulos C, MacNabb CM, Freeman J. Society for Technology in Anesthesia, January 2015; Phoenix, AZ.

19.Comparison of a non-invasive respiratory volume monitor to end-tidal co2 in measuring changes in minute ventilation. Williams GW, Fleming E, Voscopoulos C. American Heart Association, Scientific Sessions; November 2014, Chicago, IL.

20.Assessment of perioperative minute ventilation in obese versus non-obese patient using a non-invasive respiratory volume monitor. Voscopoulos C, Freeman J, Campbell K, George E. American Heart Association, Scientific Sessions; November 2014, Chicago, IL.

21.Incidence of post- operative respiratory depression and post-operative apnea in the obese general surgical population. Sridhar S, Pivalizza E, Kim J, Bonney I, MacNabb CM, Schumann R. 
CHEST; October 2014, Austin, TX.

22.Respiratory volume monitoring provides a better assessment of respiratory status than capnography-based respiratory rate monitoring during upper endoscopic procedures. Holley K, MacNabb CM, Georgiadis P, Minasyan H, Shukla A, Ladd D, Mathews D. CHEST; October 2014, Austin, TX.

23.Defining Minute Ventilation in Obese Surgical Patients: New Perioperative Findings. Schumann R, Gumbert S, Brayanov J, Kim J, Bonney I, Pivalizza EG. Anesthesiology 2014 Annual Meeting, October 11-15, 2014, New Orleans, LA

24.The Relationship between Minute Ventilation and End Tidal CO2 in Intubated and Spontaneously Breathing Patients.Voscopoulos C, MacNabb CM, George E. Anesthesiology 2014 Annual Meeting, October 11-15, 2014, New Orleans, LA

25.Non-Invasive Respiratory Volume Monitoring v. Capnography at Various Respiratory Rates in Non-Intubated Subjects. Mullen GJ, Jafferji M, Ladd D. Anesthesiology 2014 Annual Meeting, October 11-15, 2014, New Orleans, LA

26.Comparison of the Effect of Post-Operative Opioids on Respiratory Status in General Anesthesia and Spinal Anesthesia Patients Using a Non-Invasive Respiratory Volume Monitor. Voscopoulos C, Ladd D, Fleming E, Campbell K, George E. Poster Presentation, American Academy of Pain Medicine, March 2014, Phoenix, AZ.

27.The Evaluation of a Non-Invasive Respiratory Volume Monitor in Surgical Patients Undergoing Elective Surgery under General Anesthesia. Voscopoulos C, MacNabb CM, Brayanov J, Freeman J, Qin L, George E. Poster Presentation, Society for Technology in Anesthesia, January 2014, Orlando, FL.

28.Non-Invasive Respiratory Volume Monitoring to Develop a Risk Algorithm for the Safe use of Opioids. Voscopoulos C, Ladd D, Brayanov J, George E. Critical Care Medicine. December 2013; 41: A16. DOI: 10.1097/01.ccm.0000439240.56606.e5 Oral Presentation, Society of Critical Care Medicine, January 2014, San Francisco, CA.

29.The Use of a Non-Invasive Respiratory Volume Monitor to Detect and Quantify Obstructive Sleep Apnea in Postoperative Patients. Voscopoulos C. Poster Presentation, New York State Society of Anesthesiology: Post Graduate Assembly, December 2013, New York, NY

30.The Evaluation of a Non-Invasive Respiratory Volume Monitor in Obese Patients. Lee J, Ladd D, Glasgow A. Poster Presentation, Obesity Week, November 2013, Atlanta, GA.

31.Developing a Protocol Utilizing Non-Invasive Respiratory Volume Monitoring to Identify Patients at Risk for Opioid Induced Respiratory Depression. MacNabb CM, Brayanov J, Freeman J, George E. Circulation. November 2013; 128(22): A15815.  Poster Presentation, American Heart Association, November 2013, Dallas, TX.

32.The Use of a Non-Invasive Respiratory Volume Monitor to Measure the Adequacy of Ventilation in Patients under Conscious Sedation for Routine Endoscopic Procedures. Holley K, Mathews D, Campana L, Ladd D, Lee J, Schapiro H. CHEST. October 2013; 144(4_MeetingAbstracts):573A. DOI: 10.1378/chest.1698786.  Poster Presentation, American College of Chest Physicians, CHEST, October 2013, Chicago, IL

33.The Use of a Respiratory Volume Monitor to Assess Ventilation Before & After Airway Maneuvers during Upper Endoscopy. Holley K, Mathews D, Freeman J, Brayanov J, Schapiro H. Poster Presentation, American Society of Anesthesiologists, October 2013, San Francisco, CA

34.The Use of a Non-Invasive Respiratory Volume Monitor to Detect and Quantify Obstructive Sleep Apnea in Postoperative Patients. Campana L, Voscopoulos C, George E. Poster PresentationSociety of Anesthesia and Sleep Medicine, October 2013, San Francisco, CA

35.Evaluation of a Novel Non-invasive Respiratory Volume Monitor in Neonates. Fujii A, Silvia J, Gavin, D. Poster Presentation, American Academy of Pediatrics, October 2013, Orlando, FL

36.The Use of Non-Invasive Respiratory Volume Monitoring to Assess Obstructive Sleep Apnea in the Post-Anesthesia Care Unit. Campana L, George E, Freeman J, Ladd D, MacNabb CM, Lee J,Voscopoulos C. Anesth Analg. May 2013; 116; S-286 Poster Presentation, International Anesthesia Research Society, May 2013, San Diego, CA

37.Use of a Respiratory Volume Monitor to Identify Opioid Induced Respiratory Depression in the Post-Anesthesia Care Unit. Voscopoulos C, Freeman J, Ladd D, Brayanov J, MacNabb CM, George E. 
Anesth Analg. May 2013; 116; S-287 Poster Presentation, International Anesthesia Research Society, May 2013, San Diego, CA

38.Use of a Continuous Non-Invasive Respiratory Volume Monitor in Postoperative Cardiac Surgery Patients Before and After Endotracheal Extubation. Marengi N, Brayanov J, England M, MacNabb CM, Campana L, Pham DT, Ianchulev, S. Anesth Analg 2013; 116; S-289 Poster Presentation, International Anesthesia Research Society, May 2013, San Diego, CA

39.The Evaluation of a Non-Invasive Respiratory Monitor in General Surgery Patients Before and After Anesthesia. Respiratory and Critical Care Medicine. Mullen G, Brayanov J, Ladd D, Cho E, MacNabb CM, Freeman J. May 2013; 187(1): A4222.  doi:10.1164/ajrccm-conference.2013.187.1_MeetingAbstracts.A4222 Poster Presentation, American Thoracic Society International Conference, May 2013, Philadelphia, PA

40.The Use of a Respiratory Volume Monitor in the Assessment of Obstructed Breathing and Postoperative Apnea. Freeman J, George E, Brayanov J, MacNabb CM, Cho E, Ladd D, Lalli M, Voscopoulos C. Pain Medicine. April 2013; 14(4): 602. Poster Presentation, American Academy of Pain Medicine, April 2013, Ft. Lauderdale, FL

41.Continuous Non-Invasive Monitoring of Respiratory Status of Injured Lung in Patients with Traumatic Thoracic Injuries. Freeman J, Corneille M, Galvagno S, Voscopoulos C, Sordo S, Brayanov J. 
Critical Care Medicine.  December 2012 doi: 10.1097/01.ccm.0000424630.46145.88. Poster Presentation, Society of Critical Care Medicine, Critical Care Congress, January 2013, San Juan PR.

42.Evaluation of a Non-invasive Respiratory Volume Monitor during Obstructed Breathing. 
Voscopoulos C, Freeman J, Brayanov J, Ladd D, MacNabb M, Eikermann M. Critical Care Medicine.  December 2012, doi: 10.1097/01.ccm.0000424323.56647.a9.  Poster Presentation, Research Citation Finalist, Society of Critical Care Medicine, Critical Care Congress, January 2013, San Juan PR

43.Evaluation of a Non-Invasive Respiration Monitor for Continuous Monitoring of Respiratory Parameters Freeman J, Galvagno S, Panasyuk A, Lalli M, Yocum N, Bokhenik R, Desmarais L, Fahy D, Ladd D. CHEST. October 2012;142 (4_MeetingAbstracts):950A. doi:10.1378/chest.1389779. Poster Presentation CHEST, October 2012, Atlanta, GA

44.Assessment Of A Non-Invasive, Real-time Respiratory Monitor To Be Used In The Management Of Pain. Lalli M, Yocum N, Panasyuk A, Panasyuk S, Logan G, Lew R, Freeman J. Pain Medicine. 2012; (13) 2: 281–349. Poster Presentation, American Academy of Pain Medicine’s 28th Annual Meeting, February 2012, Palm Springs, CA